傳統CAR-T與內生性CAR-T的差別?
What are the difference between ex vivo and in vivo CAR-T ?
Pharma Business：Exosome Technology Platform
CAR.BiTE@CD3e-Nb EV (EXO001)
◎產品編號：EXO001
◎產品名稱：內生性CAR-T
◎特色：長聖EXO001(In Vivo CAR-T)是由基因工程HEK 293T穩定細胞產生的 CD3e Nb-EVs 產品，Nb-CAR.BiTE轉基因可以用來治療 HLA-G 及/或 PD-L1 雙靶點的實體腫瘤，不但有效對抗體內各種實體腫瘤，且與現有微脂體藥物傳輸系統及病毒載體的 CAR-T 平台相比，EXO001的免疫原性較低，安全性更高。
◎產品名稱：內生性CAR-T
◎特色：長聖EXO001(In Vivo CAR-T)是由基因工程HEK 293T穩定細胞產生的 CD3e Nb-EVs 產品，Nb-CAR.BiTE轉基因可以用來治療 HLA-G 及/或 PD-L1 雙靶點的實體腫瘤，不但有效對抗體內各種實體腫瘤，且與現有微脂體藥物傳輸系統及病毒載體的 CAR-T 平台相比，EXO001的免疫原性較低，安全性更高。
傳統CAR-T與內生性CAR-T的差別?
What are the difference between ex vivo and in vivo CAR-T ?
Related literature
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In Vivo CAR-TIn Vivo CAR-T
After exosomes are administered in vitro and enter the in vivo circulation, they deliver the nano-antibody CAR.BiTE gene to T cells, completing immune programming in vivo, training T cells to transform into multi-target CAR-T cells, and then entering soliread more